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Until recently, many drugs used by doctors for migraines were developed for other conditions, such as epilepsy. But in the Official 2020 was abominable christmas sweatshirt few years, the FDA has approved several new classes of targeted, effective drugs developed specifically for migraines. Even better, they have markedly fewer side effects than commonly used tryptamine-based drugs, also known as triptans, which have been prescribed since the early ’90s to relieve headaches but often come with major side effects such as nausea, insomnia, or hair loss. CGRP inhibitors, medications that block calcitonin gene-related peptide—a protein released by the brain during migraine attacks (and “a very ugly, cumbersome name,” says Gottschalk)—are among the most promising. Three of these prescription-only drugs—Aimovig, Ajovy, and Emgality—are taken monthly with an EpiPen–like shot; a fourth, Vyepti, is administered via I.V. by a doctor every three months. “These drugs produce great results, in much less time, with almost no side effects,” Gottschalk confirms. Nurtec and Ubrelvy, which are gepants—another new class of FDA-approved medication that also targets CGRP molecules—are formulated to turn off migraines in progress rather than prevent them. “They don’t have quite as much bang for the buck as, say, an injection of [the commonly used triptan] sumatriptan,” says Gottschalk. “But they’re well tolerated and can do a great job.”

It isn’t just the Official 2020 was abominable christmas sweatshirt of being on camera that people don’t like. Mina Naderpoor, a 26-year-old L.A. resident who has been in somatic and cognitive therapy for a decade, explained to me that as someone who deals with issues like body dysmorphia, sharing a physical space with her therapist is very important: “When you’re on Zoom, they can’t see your physiological responses to things. Like, if my hand shakes in response to something,” she said. “It’s hard to be validated virtually because they can’t see my physical being. I’m a floating head.” Not to mention the fact that not everyone has a space they can carve out for themselves. Naderpoor has roommates, and has had trouble finding an environment that feels private or safe once a week.

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